I have never taken a GABA supplement because I had read several articles stating that GABA cannot cross the blood-brain barrier and there was no way for me to waste time and money on this extra charge.
That said, I see in your post that Gaba has worked for you for a lot of fibro-related problems. So I'm going to try it because I remain open to all solutions that could improve my health! How much GABA do you take? Do you take it every day? Do you possibly have any side effects with GABA?
Hi Phil, I also saw those articles, albeit after having my very positive experience. Also more recent studies coming to the opinion that it apparently can, just not clear how that can be, as the molecules are too big. That's also the opinion of my sleep lab psychiatrist, who when I asked if praps GABA is working via my gut, said my effects are clearly a physiological brain effect and it's also not possible for it to me placebo if it is working for me that well long-term. Then people, esp. Datis Kharrazian, saying if GABA crosses it, then we have a leaky brain, similar to the leaky gut hypothesis. Neither fit to my body however, they don't work for me. In the interesting discussion between Trudy Scott as proponent of GABA and Datis Kharrazian on her anxiety blog, she is the clear winner to me and he backs down.
How much GABA do you take? Do you take it every day? Do you possibly have any side effects with GABA?
GABA is more individual than other substances.
As I need a lot, 2-3g per day in 4-6 doses, it was no problem for me to start with 750mg.
But to others I first recommend to make sure if it is really that amino acid that is needed by looking at the symptom checklist that Trudy Scott calls "amino acid questionnaire".
Next to do as she suggests: start with 125mg sublingually and increase from there (start low, go low).
(If someone's esophagus & stomach doesn't tolerate even mild acids then to encapsulate like me however.)
Personally, I adjust the levels according especially to my bladder muscles, tension and seizures. At the moment 4x0.3g spread thru the evenings and night, 1x0.6g each in morning and at "mid"day.
I need to take it every day. When my histamine load also increases I have to increase to around 3g.
And I think taking it every day is what Trudy Scott would also normally recommend.
Andrew Huberman, who uses it just for sleep, takes it every 2 or 3 days in the evenings. That I think is something to test yourself, if you have the feeling your body needs regular impulses incited rather than a continual level like me.
I had a few minor side effects like vivid dreams in the first week. Overdosing causes a slight serotonin syndrome, which is quick to detect, so not scary, but that shows it's best to start low and go slow as said. The symptoms of too much serotonin are similar to too little, so it's not easy to know which it is. I'm getting better at sensing which it is rather than just testing.
A few people off- and online have tried it for fibro and for CFS after hearing my experience, but some needed something different of course.