Hello there, yes, here in Maine, it is medically legal.I have been experimenting for 2years.I have found it to be very helpful to me.I had a time trying to figure out strains, what worked what didn't, and have gained alot of insight.I think I may have something to offer here.For fatigue, alot of people try sativa strains, sativa works as a dilater, can open up mucus membrains and give you some energy,open up you lungs, and bring up mucus, in tincture.I would tell you if you have anxiety issues, be VERY careful with sativa strains.I can only tolerate about a 40% sativa in any of my cannabis that I smoke.It is not a good experience to get stressed out and have paranoid thoughts if you have these issues already.Tincture, can be taken in glycerin, and alcohol form.That is different if I eat it or take a tincture, I can tolerate 100% sativa, and that will NEVER happen smoking it.I get alot of pain releif from tincture, and a lift for 3-4hrs.I mean a lift, say you don't sleep and you have to go somewhere and see a doctor, it can literally keep you up and functioning.It will make you edgy if you do to much or don't eat.If you have leg pain, I recommend a 80-90% indica, it seems to help alot with leg pain, especially below the knee.If you find it doesn't by smoking, I would eat it, or try in a tincture, it will make you sleepy if you take too much, don't drive on this stuff.Don't do anything important until you know how you react to the medicine.I would be careful with butter if you have headaches, and be super careful with the dosing with butter, it will knock you out, I get some good sleep when I eat butter if I dose properly.Ok so dosing for tincture, if you smoke, you can figure it out, start very small, just a 3rd of teaspoon.Everyone is completely different with this so you will have to experiment, but it can help to have an idea what you want from the medication.Remember it is not legal federally and I am just giving my experience here because it is supposed to help a medical cannabis patient, with Pain.Don't try this without a lic, or make sue it is legal, and always follow the advice of your cannabis prescribing doctor.You can get the dosing information from a doctor Sulak, a cannbis expert in this state, he is of integrate 8 and his information is out there.Hope this helps, they want it to replace opiates in this state, it should be good enough that they work togther, and science proves that.It also should be good enough it has helped me stay on a very low dose of medication.Good luck....