I've been taking Cymbalta with no lingering issues. I got about 25-30% reduction in pain. I take it because I also have major depression, so it helps me with two things...one less med to add to the list. It's like every med for Fibro; for some it works, for others not. It kinda is a crap shoot at the beginning. If you get something that works, hold onto it. Nobody messes with my meds any more!