I have tried taking Lyrica, Cymbalta and Neurontin. I did not have luck due to side effects with all of these. I started on the Savella starter pack and got to the 50 mg. twice a day which I did for 4 days and was basically non-functional so I had to back off. I am currently taking 25 mg. once a day. I don't know if it helps that much or not but at least my arms and legs don't burn wherever they are resting-that was crazy! Anyway, in the short amount of time I have been dealing with this I have found that nothing really works for pain for me except a heating pad or hot bath with epsom salt. I deal with some discomfort every day and when I do too much I have a bad day where I hurt so bad I cry. Best thing for me is crawl in bed with my heating pad. I worry about winter coming. I live in Iowa where it is nice and cold. Think I will need to get out my electric blanket. Anyone else have any other ideas or opinions about Savella?