Dutchie, it's hard to say which meds work best. Everyone seems to respond differently and some manage their fibro without pain meds. Exercise, supplements, lotions and creams are other tried and true avenues for some folks as are guided meditation and cognitive behavioral therapy. Some folks use medical marijuana. I use Cymbalta and Tramadol as pain meds, and I still have pain. I also meditate, do yoga, walk and gently exercise, eat a healthy vegetarian diet, drink lots of water, limit sugar and nightshades, take magnesium malate, Vit D and calcium along with a good B complex supplement, and try to stay as positive as possible. When I start to get down, I notice my pain more. My normal pain level is 4-6, but I'm okay with that. My doc has given me percocet 7.5 or 10/325 a couple times when I have been in major flares, but I don't like the way it makes me feel. I'm fuzzy brained enough with the fibro fog. Some folks here take fentynal, morphine, oxys, and other morphine derived pain meds and still have pain. I hate to say it's trial and error, but it is. My advice is not to put all your pain eggs in one basket and expect to find the magic pill than rids you completely of pain. Talk with your doc about options and research your options. The better informed you are, the more control you have over fibro. You have to be the expert. Good luck and hugs.